Transcriptional Integration of the Wnt and Nodal Pathways during Organizer Formation

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Nodal signaling patterns the organizer.

Spemann's organizer plays an essential role in patterning the vertebrate embryo. During gastrulation, organizer cells involute and form the prechordal plate anteriorly and the notochord more posteriorly. The fate mapping and gene expression analyses in zebrafish presented in this study reveal that this anteroposterior polarity is already initiated in the organizer before gastrulation. Prechorda...

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Nodal signaling and the zebrafish organizer.

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ژورنال

عنوان ژورنال: Developmental Biology

سال: 2010

ISSN: 0012-1606

DOI: 10.1016/j.ydbio.2010.05.171